Molecular mechanism of lysophosphatidic acid-induced hypertensive response

molecular mechanism of isoniazid-induced mitochondrial toxicity

Mechanism of a hypertensive response to exercise.

Mottram et al. (1) recently reported in the Journal new and unexpected findings: that a hypertensive response to exercise (systolic blood pressure 210 mm Hg in males and 190 mm Hg in females) in normotensive and hypertensive subjects is associated with subtle defects in systolic left ventricular (LV) function. A number of possible mechanisms were proposed. Another explanation, not canvassed, re...

Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain

BACKGROUND We previously reported that intrathecal injection of lysophosphatidylcholine (LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 receptor, possibly via conversion to LPA by autotaxin (ATX). RESULTS We examined in vivo LPA-induced LPA production using a biological titration assay with B103 cells expressing LPA1 receptors. Intrathecal administration...

Lysophosphatidic acid receptors.

Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression. LPA acts through specific G protein-coupled, seven-transmembr...

Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling.

OBJECTIVE Lysophosphatidic acid (LPA) is a bioactive lipid molecule produced by the plasma lysophospholipase D enzyme autotaxin that is present at ≥100 nmol/L in plasma. Local administration of LPA promotes systemic arterial remodeling in rodents. To determine whether LPA contributes to remodeling of the pulmonary vasculature, we examined responses in mice with alterations in LPA signaling and ...